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| AltAnalyze
- Alternative Splicing Analysis Tool |
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AltAnalyze
is a freely available program that allows
you to perform array normalization of microarray
data (Affymetrix CEL files), calculate basic
and complex statistics and perform pathway
or Gene Ontology over-representation. While
AltAnalyze works with conventional microarrays
(3' arrays) it includes specialized
functions for exon (Affymetrix Exon 1.0 and Gene 1.0) and junction arrays to
identify predicted alternative splicing or
alternative promoter changes (splicing index
and MiDAS) and view how these changes may
affect protein sequence, domain composition
and microRNA targeting.
The software has an easy to use interface
and requires no advanced knowledge of bioinformatics
programs or scripting. It is cross-platform
and works the same on any operating system.
All you will need are your microarray files
along with some simple descriptions of the
conditions that you're analyzing. Once analyzed,
you can further view how regulated probe sets
align to domains and microRNA binding sites
in the Cytoscape Plugin DomainGraph. An AltAnalyze user forum can be found here.
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